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From ground-breaking research to revolutionary prognostics and diagnostics

AMLo Biosciences is translating ground-breaking research in cancer biomarkers into a revolutionary range of prognostic and companion diagnostic products to improve patient outcomes and reduce the financial burden of cancers on global healthcare economies.

These new prognostic tests will better identify a patient’s true risk of disease progression, so that individuals can be counselled and treated appropriately, and precious healthcare resources can be targeted effectively to the patients who need it most.

AMLo Biosciences is currently working on prognostic products for three cancers where clinicians have a significant need for better information to enable them to manage and treat patients more effectively.

Melanoma

Melanoma, a type of skin cancer, is the 5th most common cancer in the UK and the US.[1,2]

Australia and New Zealand have the highest rates of melanoma in the world, while the US and much of Europe rank in the top 20 countries in terms of melanoma prevalence.[3] Globally, there were more than 320,000 new cases of melanoma in 2020 and more than 57,000 deaths from metastatic disease.[4]

Melanoma across the world[1–4]

Infographic showing worldwide incidence of Melanoma with focus on UK, USA and Australia

Cutaneous squamous cell carcinoma
(cSCC)

This is the second most common form of skin cancer with an increasing worldwide incidence.[5] More than one million cases are diagnosed in the US each year.[6] In the UK, 45,000 people are diagnosed with cSCC annually.[7]

Oropharyngeal squamous cell carcinoma (OPSCC)

OPSCC represents one quarter of the total head and neck cancers diagnosed, causing approximately 97,000 deaths per year worldwide.[8] Incidence is steadily increasing year on year, with an estimated 173,495 new cases in 2018 and with the highest incidence occurring in Western countries.[9]

AMLo Biosciences: A team of internationally acclaimed experts with a common goal

AMLo Biosciences Limited is a private limited company registered in England and Wales. The company was founded in 2017 by a team with an internationally acclaimed track record in the oncology field, spanning the identification of translational biomarkers, drug discovery and development. A team who also has experience in building successful biotech companies.

In the past few years, projects associated with the development of our melanoma prognostic test, AMBLor®, have attracted nearly £1.5 million in research funding and £4.9 million in equity funding.

Improving health economics

The total annual cost due to skin cancer to the NHS was £112 million in 2008 and is predicted to reach over £338 million by 2025.[10,11] In the US, the annual expenditure on skin cancer is $8.9 billion.[12]

The COVID-19 pandemic has put even more strain on healthcare systems, including an unprecedented burden of delayed cancer presentations. In the COVID-19 period, there was a decrease in skin cancer diagnoses of 67% in the UK.[13] At present all patients with early-stage melanoma, which comprise more than 90% of all melanomas, are treated as if they are all at similar risk of the disease spreading. In reality, fewer than 15% will suffer disease progression.[14,15]

AMLo’s AMBLor® test enables risk stratification of individual melanomas leading to more appropriate follow-up for patients at low risk of disease progression and consequent cost savings. Research is underway to extend AMLo’s technology to identify those at high risk of metastases.

With considerable annual spending by worldwide health economies on skin cancer care, we believe efficiencies can be achieved by better stratification of personal risk of melanoma progression.

The test AMLo is exclusively developing will be simple to use and fit seamlessly into current diagnostic practice. Find out more here.

£m

Cost of melanoma to NHS in 2008[10,11]

£m

Predicted cost to NHS by 2025[10,11]

$bn
Annual cost to
US healthcare system[12]

Delivering health impact

The incidence of melanoma skin cancer has reached epidemic proportions. Global cases will reach nearly half a million by 2040, an increase of 62% on 2018 figures.[16] The time to improve care and optimise the use of precious healthcare resources is now.

Improving prognostics in melanoma has the potential to transform standard of care. It will enable those patients with melanomas that are at low risk of disease progression to be given reassurance and better-informed follow up care, while those identified to be at risk of progression will receive timely treatment and standard-of-care follow up.

AMLo Biosciences plans to launch its technology globally and make a positive impact on the lives of the 300,000+ people diagnosed worldwide with malignant melanoma every year.[4]

Recent News

References

  1. GLOBOCAN 2020. UK factsheet. Available at: https://gco.iarc.fr/today/data/factsheets/populations/826-united-kingdom-fact-sheets.pdf. Accessed January 2024.
  2. GLOBOCAN 2020. US factsheet. Available at: https://gco.iarc.fr/today/data/factsheets/populations/840-united-states-of-america-fact-sheets.pdf. Accessed January 2024.
  3. World Cancer Research Fund International. Skin cancer statistics. Available at: https://www.wcrf.org/dietandcancer/skin-cancer-statistics/. Accessed January 2024.
  4. GLOBOCAN 2020. World factsheet. Available at: https://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf. Accessed January 2024.
  5. Fania L, et al. Biomedicines. 2021;9(2):171.
  6. Howell JY, Ramsey ML. Squamous cell skin cancer. In: StatPearls. Treasure Island; 2020. Available at: https://www.ncbi.nlm.nih.gov/books/NBK441939/. Accessed January 2024.
  7. ScienceDaily. Skin cancer rates in England far higher than previously thought, according to new database (2018). Available at: https://www.sciencedaily.com/releases/2018/11/181128115000.htm. Accessed January 2024.
  1. Antonioli M, et al. Autophagy. 2021;17(10):2842–2855.
  2. De Felice F, et al. J Oncol. 2019;2019:9173729.
  3. Vallejo-Torres L, et al. J Public Health (Oxf). 2014;36(1):140–8.
  4. Goon PKC, et al. Br J Dermatol. 2017;176(5):1351–3.
  5. Centers for Disease Control and Prevention. Health and Economic Benefits of Skin Cancer Interventions. Available at: https://www.cdc.gov/chronicdisease/programs-impact/pop/skin-cancer.htm. Accessed January 2024.
  6. Andrew TW, et al. Clin Exp Dermatol. 2021;46(1):145–6.
  7. Cancer Research UK. Melanoma skin cancer statistics. Available at: https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/melanoma-skin-cancer#heading-Zero. Accessed January 2024.
  8. Ellis R, et al. Br J Dermatol. 2020;182(1):156–65.
  9. Global Coalition for Melanoma Patient Advocacy. Fighting Melanoma Together. 2020. Available at: https://www.melanomauk.org.uk/2020-melanoma-skin-cancer-report. Accessed January 2024.

Job code: 2023/AMBLor/UK/0184
Date of preparation: January 2024

  1. GLOBOCAN 2020. UK factsheet. Available at: https://gco.iarc.fr/today/data/factsheets/populations/826-united-kingdom-fact-sheets.pdf. Accessed January 2024.
  2. GLOBOCAN 2020. US factsheet. Available at: https://gco.iarc.fr/today/data/factsheets/populations/840-united-states-of-america-fact-sheets.pdf. Accessed January 2024.
  3. World Cancer Research Fund International. Skin cancer statistics. Available at: https://www.wcrf.org/dietandcancer/skin-cancer-statistics/. Accessed January 2024.
  4. GLOBOCAN 2020. World factsheet. Available at: https://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf. Accessed January 2024.
  5. Fania L, et al. Biomedicines. 2021;9(2):171.
  6. Howell JY, Ramsey ML. Squamous cell skin cancer. In: StatPearls. Treasure Island; 2020. Available at: https://www.ncbi.nlm.nih.gov/books/NBK441939/. Accessed January 2024.
  7. ScienceDaily. Skin cancer rates in England far higher than previously thought, according to new database (2018). Available at: https://www.sciencedaily.com/releases/2018/11/181128115000.htm. Accessed January 2024.
  8. Antonioli M, et al. Autophagy. 2021;17(10):2842–2855.
  9. De Felice F, et al. J Oncol. 2019;2019:9173729.
  10. Vallejo-Torres L, et al. J Public Health (Oxf). 2014;36(1):140–8.
  11. Goon PKC, et al. Br J Dermatol. 2017;176(5):1351–3.
  12. Centers for Disease Control and Prevention. Health and Economic Benefits of Skin Cancer Interventions. Available at: https://www.cdc.gov/chronicdisease/programs-impact/pop/skin-cancer.htm. Accessed January 2024.
  13. Andrew TW, et al. Clin Exp Dermatol. 2021;46(1):145–6.
  14. Cancer Research UK. Melanoma skin cancer statistics. Available at: https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/melanoma-skin-cancer#heading-Zero. Accessed January 2024.
  15. Ellis R, et al. Br J Dermatol. 2020;182(1):156–65.
  16. Global Coalition for Melanoma Patient Advocacy. Fighting Melanoma Together. 2020. Available at: https://www.melanomauk.org.uk/2020-melanoma-skin-cancer-report. Accessed January 2024.

AMLo Biosciences Limited is a company registered in England and Wales. Company # 11004534

Trading address (Visitors and Deliveries): Office 9, The Biosphere, Drayman's Way, Newcastle Helix, Newcastle upon Tyne,
NE4 5BX
///wider.admire.guard

Registered address: c/o RMT Accountants & Business Advisors Ltd, Gosforth Park Avenue, Newcastle upon Tyne, NE12 8EG, United Kingdom

VAT # 285288950

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